Zika viral dynamics and shedding in rhesus and cynomolgus macaques
نویسندگان
چکیده
منابع مشابه
Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques
Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged in the Middle East. Since 2012, there have been approximately 2,100 confirmed cases, with a 35% case fatality rate. Disease severity has been linked to patient health status, as people with chronic diseases or an immunocompromised status fare worse, although the mechanisms of disease have yet to be elucidated. We used ...
متن کاملDevelopment of a Zika Virus Infection Model in Cynomolgus Macaques
Limited availability of Indian rhesus macaques (IRM) is a bottleneck to study Zika virus (ZIKV) pathogenesis and evaluation of appropriate control measures in non-human primates. To address these issues, we report here the Mauritian cynomolgus macaque (MCM) model for ZIKV infection. In brief, six MCMs (seronegative for Dengue and ZIKV) were subdivided into three cohorts with a male and female e...
متن کاملA Characterization of Aerosolized Sudan Virus Infection in African Green Monkeys, Cynomolgus Macaques, and Rhesus Macaques
Filoviruses are members of the genera Ebolavirus, Marburgvirus, and "Cuevavirus". Because they cause human disease with high lethality and could potentially be used as a bioweapon, these viruses are classified as CDC Category A Bioterrorism Agents. Filoviruses are relatively stable in aerosols, retain virulence after lyophilization, and can be present on contaminated surfaces for extended perio...
متن کاملZika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
Zika virus (ZIKV), an emerging flavivirus, has recently spread explosively through the Western hemisphere. In addition to symptoms including fever, rash, arthralgia, and conjunctivitis, ZIKV infection of pregnant women can cause microcephaly and other developmental abnormalities in the fetus. We report herein the results of ZIKV infection of adult rhesus macaques. Following subcutaneous infecti...
متن کاملCorrection: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues
[This corrects the article DOI: 10.1371/journal.ppat.1006219.].
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2016
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.4206